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When mice in Dr. Kipnis's lab were induced to have a disorder where the immune system attacks the myelin in their brain and spinal cord, immune cells could be seen around ACE points and even between the blood vessel wall and the cuff cells; this led over time to a breakdown of the ACE point itself.

The authors termed this "downstream wreckage," demonstrating how someone's chance of becoming a serious, chronic, and violent offender increased with each additional ACE point.

The ace point in the outer table is more commonly known as the "bar" point.

The movement of the men of each player is from the ace point in his opponent's home table towards the like point in his own, though for many purposes it suffices if he can play them into his own table, independently of their reaching any particular point therein, the object of the game being first to get all the player's men into his own inner table, and then to play them out of it again, according to certain rules to be hereafter stated.

In the case of the trois, he has no man on that point, and therefore must play forward, either by advancing a man from the cinque to the deuce, or from the quatre to the ace point.