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Guardiola has spoken about the injury issues that have blighted John Stones and Nathan Ake this term while it cannot be taken for granted that Bernardo Silva, Ederson or Matheus Nunes will still be at City when the summer window closes on 31 August.

Akanji's injury comes after fellow defenders John Stones, Nathan Ake and Ruben Dias only recently returned from absences.

With Ruben Dias, Akanji, Josko Gvardiol, Stones and Nathan Ake waiting in the wings, Guardiola is hoping his side can soon once again show the form that earned them a Treble.

John Stones made a welcome return, while Guardiola is hoping others such as Ruben Dias and Nathan Ake could be back, along with Oscar Bobb, while Kevin de Bruyne can acquire more minutes and fitness.

England's John Stones will also miss the game, while Nathan Ake has twice been ruled out for extended periods because of injury already this season.