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"By contrast, we are developing immunotherapy based on novel, genetically engineered, fully off-the-shelf or allogeneic immune cells. Allogeneic cells are not sourced from the same patient, but rather another source," Matosevic said.

She finally had an allogeneic bone marrow transplant, but has not responded as well as we’d hoped.

“Tolerance for unsuccessful manufacturing in the allogeneic world is higher,” says Grupp.

There were now tests to help predict compatibility and to improve the chances that allogeneic marrow cells would engraft.

“There’s a lot of evidence that allogeneic transplants for lymphoma are effective, so mitigating these side effects could bring curative treatment to many more patients,” Lee says.