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The wider state visit to Italy will continue in April with some alterations to the planned programme.

From the win over Canada that secured England's WXV1 title success in October, Mitchell has made seven changes in personnel and some positional alterations to his starting XV to face Italy.

In total, he has made seven alterations from the side he picked after round one.

Yet in the course of 65 years on the boulevard, Dastoli wrote, the building itself has seen only “minimal alterations.”

Their mouse is a tool, they say, with which to test whether different genetic alterations they have planned are effective and safe before they try them out on elephants.