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The university in New Haven, Connecticut, noted that a 1973 study conducted by McCrone Research Institute in Chicago first discovered that the titanium compound anatase was used in the map's ink, and Yale's own in-house analysis confirms it using the latest technology available.

Nanoparticles tend to heat up a little when they absorb UV radiation, says Paul Westerhoff, a professor at Arizona State University’s School of Sustainable Engineering and the Built Environment, and some research suggests that this process could cause oxidative damage to the skin, particularly with one form, called anatase, when it was delivered in uncoated particles.

For example, in cassiterite it is given as a : c = 1 : 0.67232 or simply as c = 0.67232, a being unity; and in anatase as c = 1.7771.

Examples of substances which crystallize in this class are cassiterite, rutile, anatase, zircon, thorite, vesuvianite, apophyllite, phosgenite, also boron, tin, mercuric iodide.

The diamonds are found in the sands and gravels of river-beds, associated with alluvial gold, specular iron ore, rutile, anatase, topaz, and tourmaline.