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Then, the researchers treated those human cell models with a special variety of protein called CXCL12, which restored YAP and TAZ and restarted normal angiogenesis.

To do so, they must grow and branch to reach every cell in a process called angiogenesis.

This resurgence for angiogenesis inhibitors comes after astronomical expectations for the drugs were dashed in the late 1990s.

“It works by angiogenesis or creating new blood vessel formation,” says John L. Ferrell III, director of sports medicine for D.C.- based Regenerative Orthopedics and Sports Medicine.

A similar approach has been used to stimulate the growth of blood vessels in the heart and neck, so the therapy, known as therapeutic angiogenesis, is well established postnatally.