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"This study provides important evidence that we need to identify and treat these associated conditions if our more direct efforts to suppress the arrhythmia by antiarrhythmic drugs or ablation are to be effective," Wilber added.

Late last week Gilead Sciences issued a warning about a rare but potentially fatal interaction between its stellar new hepatitis C drug sofosbuvir and amiodarone, a potent but tricky antiarrhythmic agent.

Quinidine was once a frequently used antiarrhythmic agent, but it’s use declined sharply with the advent of newer agents and evidence showing an association with harm in clinical settings.

Patients in the medical management arm received antiarrhythmic drug changes and direct current cardioversions to achieve and maintain sinus rhythm, and were followed at 1, 3 and 6-months.

To predict how antiarrhythmic drugs will alter cardiac rhythms, researchers must first determine how the drugs will interact with these ion channels.