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What’s more, the aseptic cartons themselves are designed to be recyclable, and are usually made from around 70 percent paperboard.

The specialist process of filling the syringes used in the pens, called aseptic or sterile fill-finish, is particularly in demand.

The first case of meningitis in Durango was confirmed late last year when doctors diagnosed several cases of aseptic meningitis, an especially harmful inflammation of the brain.

The lack of information about the environment at the production bases, combined with the need for vaccine shots to be made in strictly aseptic settings, persuaded officials to take the measure, Anvisa said.

But doing so will involve a series of technical challenges — including finding ways to grow the principal component of a vaccine, which must be aseptic, in mosquitoes.