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Comproportionation reactions result in multiple copies of some of the molecules involved, providing materials for the next steps in autocatalysis.

But according to Pohorille, the potential for aggregation doesn’t automatically mean Dill is wrong about needing those hydrophobic patches to get autocatalysis started.

The other main reason for autocatalysis is that new technologies and materials make it possible to generate still other new technologies by recombination.

He demonstrated the processes of synthesis and autocatalysis that enabled such small samples to be multiplied indefinitely.

Since RNA would have been better at autocatalysis, it would have been favored by natural selection in the long run.