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Created at the turn of the 19th century by London confectioner William Smith, he marketed his mints — which were made from sugar, gum arabic, peppermint oil, gelatin and glucose syrup — as "a stomach calmative to relieve intestinal discomfort."

Viewed as an unconventional portrait of maturing adolescence, however, “Maidentrip” works, presenting isolation as a calmative to the squalls of puberty.

Some of the studies explore the neuroscience of calmative behavior.

No calmative of sleep or sage Will cure the fever to be free.

In such cases, however, a shot or two from a good revolver has a wonderfully persuasive and calmative effect on even Somali Indians.