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Because this type of cell is present in the top of the skull, or "calvarium," in mice, they suspected that it has a role in causing craniosynostosis.

The findings suggest that inappropriate DDR2+ stem cell proliferation in the calvarium, in infants with craniosynostosis-linked gene mutations, could be treated by suppressing this stem cell population, through mimicking the methods that CTSK+ stem cells normally use to prevent expansion of DDR2+stem cells.

"We observed that we could partly prevent calvarial fusion by injecting IGF-1 over the calvarium," said study first author Dr. Seoyeon Bok, a postdoctoral researcher in the Greenblatt laboratory.

“You know, sometimes she’ll tell me she wants brain, and we’ll, you know, leave the calvarium ‘til last, and then try to basically take it or, actually, you know, catch everything, and even keep it separate from the rest of the tissue so it doesn’t get lost,” she says.

“There is one case currently in the room, I will let you know how the limbs and calvarium look to see if you are able to take them in about 15 minutes,” the clinician said in the email.