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Several drugs, including entacapone, contain metal-binding catechol groups, suggesting that this mechanism could be a more common pathway for drug-induced microbiome alterations.

Such antimicrobial activity was attributed to a direct contact killing process, where the pathogen is initially attached to the coating by catechol molecules and other polyphenol derivatives.

It increased most often in the presence of catechol, a large molecule in a building block of wood that was emitted by smoldering fires.

He and Matt Coggon, a research scientist at NOAA, also found that catechol may play a key role in ozone formation related to wildfires.

The chart measured the molecular composition of hundreds of different VOCs, but Coggon’s eyes were fixed on catechol, which was now at very high volumes and ticking down rapidly.