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In their model, however, the researchers observed that while ceramide levels were high in the bloodstream, levels in artery-lining endothelial cells remained about the same regardless of coronary artery disease status.

A ceramide test is more complex to perform because it requires mass spectrometry, which is not available in most clinical labs.

Still, she says that although one of her patients asked about ceramide testing, she has never ordered it and remains unsure about its clinical value.

Researchers have noted that blood ceramide levels tend to fall after patients improve their diet, exercise more, or take cholesterol-lowering medications such as statins.

Nobody expects ceramide testing to usurp the standard lipid panel.