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In collaboration with researchers at the University of Alabama at Birmingham, Mukhtar's team demonstrated through organotypic skin culture experiments from HS patients that blocking CD2 led to a significant reduction in cytokine and chemokine production, along with suppression of key pathogenic gene signatures.

Using the chemokine Ccl3 as a "proof of principle," they discovered that its function in the immune defence against viruses is different than had been previously assumed.

In order to understand how these signalling proteins coordinate immune cells, researchers from Bonn took a closer look at the chemokine Ccl3.

This triggers the NK cells to rapidly produce the chemokine Ccl3.

"However, NK cells are not only the cellular source, i.e. the producers of Ccl3, but also the main sensors for the chemokine in this context," says co-senior author Prof. Dr. Niels A. Lemmermann, research group leader from the Institute of Virology at the UKB and member of the Cluster of Excellence Immunosensation2 at the University of Bonn.