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If the axis cylinder is severed at any point, it degenerates beyond that point, and the nucleus of the nerve-cell disintegrates—chromatolysis.

Animals upon whom double adrenalectomy has been performed show a striking fall in temperature, muscular weakness,—after adrenalectomy the animal may not be able to stand even,—and progressive chromatolysis.

The injection of adrenalin causes striking brain-cell changes: first, a hyperchromatism, then a chromatolysis.

Adrenalin alone causes hyperchromatism followed by chromatolysis, and in overdosage causes the destruction of some brain-cells.