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Not in cases of chromosomal aberrations like Down syndrome, he clarified, but in cases where the anomalies were incompatible with life.

The CIS samples that regressed generally lacked notable chromosomal aberrations.

The tumours evolved quickly: by the fourth passage, 88% of the PDX models had at least one large chromosomal aberration, and a median of 12% of the genome had been affected.

When more than one cell was analysed, sibling cells from an individual patient rarely shared multiple chromosomal aberrations, but frequently possessed distinctive genomes.

Rava says the company plans to expand that test, called verifi, to incorporate the additional chromosomal aberrations that the new study shows it can identify, which could take at least a year.