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Blankenhorn placed half of them on a diet containing 22% fat and gave them colestipol and large doses of niacin, both standard cholesterol-reducing drugs.

Brown divided his subjects into three groups, one taking niacin and colestipol, the second receiving colestipol and another cholesterol reducer, lovastatin.

If cholesterol cannot be reduced with diet alone, the panel directed, physicians should prescribe such drugs as cholestyramine and colestipol, which act in the intestines and cause the body to utilize excess cholesterol.

Last week in the Journal of the American Medical Association, Dr. David Blankenhorn of the University of Southern California reported that patients who were treated with a combination of the anticholesterol drug colestipol and the vitamin niacin showed a marked improvement over those who had maintained a low-fat diet alone.

Last year Dr. David Blankenhorn, director of atherosclerosis research at the University of Southern California, reported on a study in which 162 nonsmoking men who had undergone coronary- bypass surgery were put on a low-fat diet; 80 of them were also treated with niacin and colestipol.