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colony-stimulating factor
noun
- immunol any of a number of substances, secreted by the bone marrow, that cause stem cells to proliferate and differentiate, forming colonies of specific blood cells. Synthetic forms are being tested for their ability to reduce the toxic effects of chemotherapy CSF
colony stimulating factor
- Any of various glycoproteins that act to promote the production and differentiation of specific blood cell types. Colony stimulating factors circulate in the blood, acting as hormones, and are also secreted locally. An example is erythropoietin, which is produced in the kidney and regulates the formation of red blood cells from progenitor cells in the bone marrow.
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Example Sentences
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These tumor-associated macrophages also supply growth factors to cancer cells, to enable them to divide and grow; cancer cells reciprocally stimulate the macrophages by producing their favorite growth factor, known as Colony Stimulating Factor.
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By preventing treatment-induced macrophage recruitment through blockade of the cognate macrophage receptor, colony stimulating factor receptor-1 responses were improved.
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