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"We linked each property to different contractile mechanisms and asked how they are connected to cancer cell escape and tumor aggressiveness."

The model also predicted how another type of contractile fiber could be targeted by the experimental Src inhibitor WH4023, which they experimentally validated with human cardiac fibroblasts.

"We aimed to clarify the association of phase angle obtained from the leg using BIA with voluntary muscle strength, twitch contractile properties, and neuromuscular activity," says Assistant Prof. Hirata.

The research team found that some of the proteins in the muscle cells act as a temperature sensor, and that heating affects skeletal and cardiac contractile systems differently.

In a paper published today in Nature, researchers report refashioning Photorhabdus’s syringe—called a contractile injection system—so that it can attach to human cells and inject large proteins into them.