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The Oscar-winning actor, 95, died at his Santa Fe home from coronary artery disease, with advanced Alzheimer's disease a contributing factor.

The most common cause of heart failure is blockage of coronary arteries that leads to death of the cardiomyocyte heart muscle cells.

Instead of being caused by a single genetic spelling mistake, in some patients the condition is more like common diseases such as coronary artery disease, where many genetic differences collectively contribute to risk.

He had been diagnosed with coronary artery disease and was found to have drowned in a hot tub.

The Northern Trust say they currently offer it to heart failure patients who have had an ischaemic event, which is disruption of blood flow to the heart caused by disease of the coronary arteries.