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The Oscar-winning actor, 95, died at his Santa Fe home from coronary artery disease, with advanced Alzheimer's disease a contributing factor.

Instead of being caused by a single genetic spelling mistake, in some patients the condition is more like common diseases such as coronary artery disease, where many genetic differences collectively contribute to risk.

He had been diagnosed with coronary artery disease and was found to have drowned in a hot tub.

Officials ruled that his death was an accident but the drowning, coronary artery disease and the effects of an opioid treatment drug, were also contributing factors.

Other factors that contributed to his death, according to the medical examiner, included drowning, coronary artery disease and the effects of buprenorphine, a medication used to treat opioid addiction.