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For it is very conceivable that the Crasis, the Consistence, of the fibrous Blood may sometimes be affected with a morbid Laxity or Weakness, as well as the general System of the muscular Fibres.

Would it not be more philosophical to conjecture that the crasis, if that exists at all, takes place universally; but that the consequences are only tolerated in certain parts of the globe, which he defines as the Sotadic Zone?

"The only physical cause for the practice which suggests itself to me, and that must be owned to be purely conjectural, is that within the Sotadic Zone there is a blending of the masculine and feminine temperament, a crasis which elsewhere occurs only sporadically."

But Burton makes no effort to account for the occurrence of this crasis of masculine and feminine temperaments in the Sotadic Zone at large, and for its sporadic appearance in other regions.

Nevertheless, he was led to surmise a crasis of the two sexes in persons subject to sexual inversion.