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This intermediate step is crucial, as Nagashima remarks: "Our detailed mechanistic studies revealed that the photoexcited borate complex both accelerates the cycloaddition and suppresses the rearomatization that usually occurs in conventional photocycloaddition reactions."

"We first had to change their specific bonding structure -- carrying out so-called dearomatization -- in order to obtain significantly more reactive intermediates. The subsequent cycloaddition and rearomatization processes ultimately result in the formation of the skeletal-edited compounds."

The reaction is called copper-catalyzed azide-alkyne cycloaddition -- abbreviated CuAAC and pronounced "quack."

Later, independently of each other, Meldal and Sharpless discovered “what is now the crown jewel of click chemistry: the copper-catalyzed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use,” the academy said.

Later, Meldal and Sharpless, independently of each other, discovered “what is now the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use.”