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"Acquired methemoglobinemia is a rare complication after exposure to certain topical anesthetic agents and oral antibiotic agents, including oral dapsone, but was not seen in clinical trials of topical dapsone," the company said.

When doctors recognize it -- which they may not because it is so rare -- it can be cured by a long-term regimen of the antibiotics dapsone, rifampicin and clofazimine.

The study authors noted that prior research has shown that dapsone pills, in very rare instances, can trigger methemoglobinemia, the abnormal production of a red blood cell protein that delivers oxygen throughout the body.

But the current case appears to be the first time that this condition has been associated with Aczone, the skin gel version of dapsone, they said.

It wasn't until the results of a urine test came back that doctors saw indications of dapsone, he said.