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Removal of CaMBD enables increased activity of the enzyme glutamic acid decarboxylase, which catalyzes the decarboxylation of glutamate to GABA, thus raising levels of the molecule.

The other was a mutation of a gene called ornithine decarboxylase, or ODC1.

This is achieved, at least in part, through reduction of the levels of mitochondrial phosphatidylserine decarboxylase, which is involved in the synthesis of mitochondrial phosphatidylethanolamine.

Adams argues that he could have an autoimmune disorder attacking a brain enzyme called glutamic acid decarboxylase.

In the Parkinson's trial, funded by Neurologix Inc, the delivered gene controls production of an enzyme called GAD or glutamic acid decarboxylase.