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Just like flower, hash and kief need to undergo decarboxylation, the process by which heat is used to activate the psychoactive properties of cannabis.

You can tell the decarboxylation worked if the cannabis changes color from bright green to dark brown-green.

Removal of CaMBD enables increased activity of the enzyme glutamic acid decarboxylase, which catalyzes the decarboxylation of glutamate to GABA, thus raising levels of the molecule.

Then the THC oil must be converted into its psychoactive form via decarboxylation, a cooking process that makes the oil ready to be used in edible products.

Moreover, they illustrate how a seemingly simple process — that is, the harvesting and decarboxylation of lysine — can drive major metabolic reprogramming that leads to an increase in the cell’s capacity for producing NADPH.