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Therefore, in their study they also verify the importance of using the oxygen desaturation index, which shows how serious the episodes are by measuring the number of events in which oxygen saturation has decreased by more than 3%.

In addition to establishing sweat as a good sentinel when it comes to determining the stage of the disease, this work also reveals the importance of taking into account the oxygen desaturation index when diagnosing it.

Dr Jayaram said he noticed the girl's breathing tube had become dislodged and that Letby was doing "nothing" to correct the desaturation until he arrived.

At 19:40 there was a further "profound desaturation" and Child N required resuscitation and six doses of adrenaline before he stabilised.

Ms Letby "called for help" after the boy's first "profound desaturation" shortly before 07:15.