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"In the presence of Nodal, however, the chaperones are released, and Nodal can then dimerize with Vg1."

Moreover, vasodilation of blood vessels isolated from a mouse model of sepsis — endotoxaemic mice, in which the animals are exposed to bacteria-derived toxins — was suppressed when the animals expressed a mutant version of PKG1α that could not dimerize at Cys 42 on exposure to oxidants.

Although Pgp must undergo large amplitude movements that dimerize the NBDs to enable ATP hydrolysis, the observation of apo-like distance distributions in the presence of excess ATP/Mg2+ demonstrates that stabilization of the outward-facing conformation requires ATP hydrolysis.

Step 1: conformational sampling by ATP-bound Pgp enables the NBD to dimerize following the binding of substrate.

Step 1: conformational sampling by ATP-bound Pgp enables the NBD to dimerize following the binding of substrate.