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It is a molecular trap that prevents one of the most common genetic ALS-causing peptide compounds, the Poly-GR dipeptide, from causing its toxic effects in the body.

By contrast, in reaction scheme 2, AlaRS was incubated with the 70S initiation complex for 15 min, followed by addition of EF-Tu⋅GTP⋅Ser-tRNAAla, and aliquots were removed at various times for eTLC analysis. n = 2 independent experiments. c, Deacylated tRNAAla was mixed with AlaRS, serine, ATP and all other components to form the ternary complex, aliquots were transferred at various time points to the 70S initiation complex, and dipeptide products were resolved by eTLC. t = 0 indicates control reactions in the absence of AlaRS; * indicates oxidized fMet.

He typed out each of these potential dipeptide repeat proteins.