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A different antihistamine compound has been developed specifically for sleep troubles — the prescription drug Silenor contains a low dose of doxepin.

Antidepressants such as amitriptyline and doxepin also have been prescribed off-label for nerve pain.

Tricyclic drugs including clomipramine, nortriptyline and doxepin were effective in the lab against types of brain, blood and skin cancers, Prof Pilkington says.

One well-travelled path involves histamine blockers, such as doxepin, which has been used for decades as an antidepressant in doses of up to 150 milligrams.

The depth of ligand penetration into the TM bundle is the deepest for doxepin in the histamine H1 receptor and shallowest for caffeine in A2AR.