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Even through our video call, you can see Fanning’s chatty ebullience come through as she sips from a coffee cup, foam sometimes dotting the top of her lip.

Live performance is therefore a precious experience: the collective gasp, the pin-drop silence, the ebullience of shared laughter and applause.

But medical breakthroughs are rarely straightforward, and the ebullience surrounding GLP-1 agonists is tinged with uncertainty and even some foreboding.

Favorite venues: “I want to stress that I love every comedy space in Seattle,” said Mejia, listing them off with an ebullience that came through the phone.

More often he conveys Lenny’s love of music, and his love of people, through the sheer ebullience of his language.