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ME/CFS affects multiple parts of the body, including the brain, the immune system, and the endocrine system.

Consequently, a balanced gut microbiota is important for mammalian health in many ways, such as helping to regulate the immune and endocrine systems.

The endocrine system is complex, involving a series of glands throughout the body that secrete chemical messengers called hormones.

Because these negative effects are mainly attributed to "physiological stress, oxidative stress and disruptions in the endocrine system," it indicates that heat stress may cause reproductive health impairments.

High concentrations of fungicides, however, may be harmful to the endocrine system, although more studies are necessary to understand just how dangerous they are to human health.