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Increasing estrogen levels in older women, for instance, might, in theory, encourage more movement, though estrogen replacement therapy remains a complicated subject because of heightened cancer risks and other health concerns.

Jennings took hormone blockers at 11 and estrogen replacement therapy when she was 12, so she never went through male puberty, her mother said.

By designing the drug in this way, the researchers can avoid the negative consequences of estrogen replacement therapy, such as increased risk for cardiovascular diseases and breast cancer.

As a conservative estimate of the true number, they arrive at 50,000 lives lost by not getting estrogen replacement therapy.

Indeed, most of the trials involving estrogen replacement therapy for women showed greater cognitive decline among women taking the hormones.