�y��vlog

Thus, they not only attack the pathogen's virulence factors, but also enhance the activity of monooxygenases -- enzymes required for the activation of the conventional antibiotic ethionamide.

Ethionamide is a drug that has been used for many decades to treat TB.

The research has been published in the article 'Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system' in Cell Chemical Biology.

To reduce the likelihood of M. tuberculosis developing a mutation in the ethA2 gene to again outwit the drug, the authors suggest pulsing doses of SMARt-420 during continual ethionamide treatment.

Déprez suggests that if SMARt-420 increases ethionamide potency in humans, the drug pairing might ultimately reduce the amount of ethionamide needed to treat TB, potentially reducing side effects.