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The scientists leveraged prior research from Gladstone investigator Katerina Akassoglou, PhD, who discovered that a blood-clotting protein called fibrin creates a cascade of toxic effects when it leaks into the brain through damaged blood vessels.

The researchers engineered the surface of the synthetic platelets to incorporate antibody fragments that bind to a protein called fibrin.

Although there are certain materials that naturally degrade within the body like fibrin glue and collagen sponges, they necessitate proteins sourced from humans or animals, making them considerably expensive.

Montgomery notes that the kidneys developed tiny blood clots called fibrin thrombi, but that this may be the result of the patient’s condition.

The researchers genetically engineered the E. coli to produce a protein polymer from fibrin designed to link into a meshlike network — imagine a heavy duty cargo net.