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This comprehensive genomic roadmap is providing critical clues into the population-level diversity, genetic load and disease susceptibility of Corvus hawaiiensis.

Recombination in diverse maize is stable, predictable, and associated with genetic load.

Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load.

“With additional specimens, drawn from other times and parts of the woolly mammoths’ enormous range, we may get a better picture of the genetic load that this species was labouring under at the end of its tenure.”

Eucalypts are preferentially outcrossing with late-acting post-zygotic self-incompatibility resulting in outcrossing rates that can exceed 90%1, high levels of nucleotide variation23, 24 and accumulation of genetic load and expression of inbreeding depression4.