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Two-cell ATAC-seq enrichment for a random set of promoters were similarly analysed as a control. c, Heat maps showing expression levels of possible minor ZGA genes activated at the two-to-four-cell stage for their expression in germinal vesicle oocytes, MII oocytes, and two-to-four-cell embryos.

The eggs of animals lower than the birds have usually only three parts, viz. the germinal spot or dot, the germinal vesicle, and the vitellus or yolk; the first being contained in the vesicle, and that again in the yolk.

These began in 1875 and following years with a careful examination of the behaviour of the germinal vesicle in the maturation and fertilization of the ovum.

The nucleus of the o�cyte is called the germinal vesicle.

The germinal vesicle of a mammalian ovum being about 1⁄1000 of an inch, mean diameter, might contain five hundred million of gemmules, which, if used up at the rate of one per second, would last more than seventeen years.