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Shao et al. showed that deletion of the KU protein completely restored haematopoiesis in mice that had mutations in the T2609 cluster, ruling out defective DNA repair alone as the explanation for the blood disorders.

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

Conservatively, the remaining four samples were also classified as containing clonal haematopoiesis, despite the small number of mutations found in them, and therefore removed from downstream analyses.

The microbiome also influences the maturation of myeloid cells after haematopoiesis.

Once it has been established that vector insertion is mostly neutral to cell behaviour, tracking clonal activity in the reconstituted haematopoiesis can highlight important biological features of haematopoietic regeneration.