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In findings that may eventually lead to targeted therapies that treat age-related muscle atrophy, a group of researchers from Kyushu University have developed a new antibody that targets and prevents the dysfunction of the protein hepatocyte growth factor or HGF: a critical factor in skeletal muscle development, regeneration, and repair.

But during chronic injury or severe hepatocyte death, proliferation of hepatocytes is exhausted.

In the zebrafish studies, the liver disease was created by inducing hepatocyte death with genetic and chemical intervention.

“The generation of auxiliary liver tissue using the lymph nodes as hepatocyte engraftment sites represents a potential therapeutic approach to supplement declining hepatic function in the treatment of liver disease.”

They extracted hepatocyte cells from the healthy tissue, and injected them into the abdominal lymph nodes of the same pig, according to the report.