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For one thing, 35delG homozygotes sometimes only have mild hearing impairment.

Some mouse and human studies have also found that CCR5Δ32 homozygotes get more severe symptoms from influenza virus; however, other researchers dismiss this concern, pointing to conflicting epidemiologic analyses.

But the 1% who inherit the mutation from both parents—so-called homozygotes—are highly resistant: Studies show that if they’re exposed to HIV, they’re 100 times less likely to become infected.

Cultivated lines are homozygotes for the allele resulting in a biennial life cycle.

For the 6 homozygotes with two copies of the allele, however, the highest dose of 300 mg was  insufficient to achieve satisfactory platelet inhibition.