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One inherited disorder associated with cardiovascular disease is familial hypercholesterolaemia.

But familial hypercholesterolaemia might be just the tip of the genetic iceberg.

Developed initially by Alnylam for familial hypercholesterolaemia, in 2013, it was licensed to The Medicines Company in Parsippany, New Jersey, with a view to using it in people with high cholesterol levels not caused by genetic conditions.

If follow-up trials in monkeys work as well, the scientists will launch a trial in patients with homozygous familial hypercholesterolaemia, or HoFH.

But, as demonstrated in familial hypercholesterolaemia, one drug can be extremely effective when used for prevention.