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People have already derived equations to estimate these probabilities, with names like the hypergeometric distribution, which has applications like election auditing and card counting.

Only significantly enriched cases are shown, based on hypergeometric distribution followed by FDR correction.

Here, we used a parameter α that enriches the hypergeometric distribution following .

If there were m cells carrying an early somatic mutation out of a total of n, the probability to subselecting k in a draw of l cells is given by the hypergeometric distribution.

We restricted ourselves to interpretation of results with an enrichment ratio of at least 2, and multiple hypothesis testing corrected P values <0.01 for both the binomial and the hypergeometric distribution based tests.