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In Myxine a further remarkable peculiarity in regard to the hypophysis, probably adaptive in nature, occurs, inasmuch as the pituitary invagination develops an opening at its posterior end into the pharynx.

It is just cephalad to the anterior end of the pharynx and to the hypophysis.

Beard put forward also the ingenious theory that the hypophysis represents the old Annelidan mouth.

ABEL, J. J., AND KUBOTA, S.: On the presence of histamine in the hypophysis cerebri and other tissues of the body and its occurrence among the hydrolytic decomposition products of proteins.

Besides the small amount of blood pressure-raising substance secreted by the hypophysis cerebri. it has not been shown that any other gland of the body furnishes vasopressor substance except the suprarenals.