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"Orphan," Jaume Collett-Serra's 2009 film, existed uncomfortably in this space, though its then-child star Isabelle Fuhrman elevated the role of Lena, a grown woman presenting as a young child due to hypopituitarism, a real condition.

In the original Orphan’s final acts, it’s revealed that 9-year-old “Esther” is actually a 33-year-old Estonian serial killer with proportional dwarfism caused by hypopituitarism, which she’s used to pretend to be a child for years as she bounces from one adoptive family to the next.

A traumatic brain injury can cause hypopituitarism, a condition in which a hormone deficiency impairs normal function.

To raise awareness and funds, it recruited Katie Price, the glamour model otherwise known as Jordan, last year to be an ambassador for the charity: Price's son Harvey suffers from septo-optic dysplasia, a condition which includes hypopituitarism.

Christopher suffered a severe head injury after falling out of a tree as a child, and his mother believes this may have caused damage to his pituitary gland, leading to hypopituitarism and impotence – a common symptom of the illness.