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The Israeli government expressed alarm over the defacement, which officials also attributed to Jewish iconoclasm in obedience to early prohibitions against idolatry.

Integral to his work’s profound effect is its sharp-eyed iconoclasm.

But Mr. Kennedy’s most powerful draw may be his iconoclasm, particularly his willingness to buck institutional thinking on matters like the benefits of vaccines.

On the contrary: He reveled in precocity, cheekiness, iconoclasm and snark.

In one of the book’s most striking claims, referencing the late-Renaissance moment of violence, iconoclasm and religious strife, she declares of the “Last Judgment” that the “painting is about petty, human failure.”