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"Mast cells pack a punch, when activated by IgE antibodies they can be said to explode and release inflammatory factors into the skin -- this is what causes itching and hives."

Food allergy symptoms that are not mediated by IgE are usually delayed reactions and called food intolerances or hypersensitivity.

Medication doses were set based on each participant's body weight and IgE levels, with injections given once every two or four weeks, depending on the dose needed.

Researchers further leveraged samples from ALK clinical trials with tablet sublingual immunotherapy which allows for sequencing large amounts of IgE producing B cells.

“They also had much higher inflammation in their blood markers, and they also had higher IgE levels, an immunoglobulin associated with reactive airway disease, asthma and other breathing problems.”