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HHS is ordered to "assess the prevalence of and threat posed by the prescription of selective serotonin reuptake inhibitors, antipsychotics, mood stabilizers, stimulants, and weight-loss drugs."

Then, we added the suspected inhibitors – quercetin, as well as some other phenolics we wanted to test – to see whether they slowed the process.

The investigational drug itacitinib is one of several JAK inhibitors under investigation for their potential to prevent graft-versus-host disease when given before a stem cell transplant, which would be a new use for this therapy.

Blocking NRP1 with established compounds is one option, as NRP1 inhibitors -- including monoclonal antibodies -- have already been developed to treat cancer.

To address this question, the research team explored at a cellular level how immune checkpoint inhibitors interact with immune cells within arterial plaques.