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But if a problem is insoluble, it’s not a problem anymore; it’s just the way things are.

In mice, the ketone ester treatment resulted in clearance rather than pathological aggregation of insoluble proteins.

Unfortunately, this feeling is often associated with insoluble dietary fibers.

To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins.

It’s a detective drama with no resolution, a morality tale with an insoluble ambiguity at its heart.