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Therefore, intradermal vaccination was more effective in activating specific antiviral immunity.

The alternative method, known as intradermal vaccination, allows a single-use vial to be split into five injections because of the vaccine shortage.

A new trial led by the National Institutes of Health, which began earlier this month, will enroll 200 adults and compare the standard dose with intradermal delivery of one-fifth and one-tenth doses.

The study will compare the intradermal method to more traditional administration methods.

Second, the intradermal injection technique is quite simple to learn.