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A microscopy method for studying cells in living animals, called intravital imaging, has already provided spectacular evidence that DC1s act as platforms that support simultaneous interactions with CD4 and CD8 T cells3,4.

Intravital microscopy, which reveals the movements of cells within the body, suggests the lives of these immune cells are eventful.

First used by cancer biologists in the late 1990s, intravital imaging involves focusing powerful microscopes directly onto exposed tissue in a live, anaesthetized mouse.

More labs have adopted intravital imaging as technological improvements have made it possible to peer further into tissue — now as many as 20 cells deep — and to tease out fainter signals.

But the increasing use of intravital imaging over the past decade has already helped researchers to piece together timelines for key cellular and molecular events, such as the process by which tumour cells sneak into blood vessels.